Sommeil LP (Sleep )

Melatonin – The Sleep Hormone: An Essential Molecule

Melatonin is a natural hormone produced by the pineal gland, also known as the sleep hormone. It is derived from tryptophan and plays a key role in regulating circadian rhythms and the sleep-wake cycle. With advancing age, its production gradually decreases, which can cause frequent night awakenings and impaired sleep quality. Melatonin taken as a food supplement is quickly absorbed by the body, and its action helps reduce the time needed to fall asleep.

Melatonin helps reduce the effects of jet lag and could be used in cases of sleep disorders or disruptions of the biological rhythm.

By shortening the time it takes to fall asleep, quality of life can be improved, particularly in people whose natural production is reduced.

Eschscholzia (California Poppy) – Sleep, Relaxation and Natural Well-being

Eschscholzia (Eschscholzia californica), better known as the California poppy, is a medicinal plant native to the western United States, where Native Americans traditionally used it for its relaxing properties. Introduced to Europe in the 19th century, it quickly became a reference plant for promoting relaxation and improving sleep quality. Eschscholzia is distinguished by its delicate, bright orange flowers.

In herbal medicine, mainly the aerial parts of the plant (flowers and herbaceous parts) are used, as they are rich in alkaloids that are beneficial to the body. Today, Eschscholzia is recognized for its role in improving sleep quality, contributing to restorative sleep without dependence.

Thanks to its natural properties, it offers a gentle way to support periods of nervousness, temporary stress or sleep disorders.

Magnesium, Vitamins B6 and B12: Reducing Fatigue, Supporting the Nervous System and Psychological Balance

Magnesium (Mg) is an essential mineral involved in more than 300 enzymatic reactions in the body. It plays a major role in reducing fatigue by contributing to cellular energy production. Magnesium also contributes to the proper functioning of the nervous system by promoting nerve impulse transmission and helping the body adapt better to stress. It also supports normal psychological functions, particularly memory, attention and emotional balance.

Together, vitamins B6 and B12 reinforce this action: they also contribute to reducing fatigue, support energy production and play a key role in the functioning of the nervous system. Their presence promotes optimal synergy with magnesium, helping to better meet the body's needs during periods of physical or mental fatigue, or temporary stress or anxiety, in order to preserve both intellectual performance and overall well-being.

Vitamins B6 and B12 are in coenzyme form. B vitamins are a group of water-soluble vitamins that act together and take part in numerous metabolic reactions. Water-soluble B vitamins do not accumulate in the body, so they avoid storage and the risk of overdose. 

In our products, they are mainly provided in the same form used by metabolism, making them more metabolically active: vitamin B6 as pyridoxal-5'-phosphate and vitamin B12 as methylcobalamin.

Sepismart^TM SR

The SEPISMART™ SR technology is a major advance in the field of functional galenics applied to food supplements. It relies on a two-layer hydrophilic matrix combining natural xanthan and acacia gums, which allows a controlled and sequential release of the actives.

This combination of polysaccharides, selected for their viscosity and compressibility properties, ensures a rapid release from the first layer – containing melatonin and magnesium in particular – to quickly initiate sleep onset, followed by a prolonged release from the second layer, which contains complementary actives such as eschscholzia, vitamins B6 and B12, and a second dose of melatonin.

Thanks to the formation of a protective gel around the core, activated by salivary and gastric moisture, SEPISMART™ SR creates a matrix system for prolonged diffusion without solvents, additives or controversial excipients. This natural, eco-designed process ensures a physiological absorption kinetics, mimicking the endogenous secretion profile of melatonin and avoiding early plasma peaks associated with side effects or night awakenings.

By prolonging the presence of the actives in the body at a steady rate, this technology helps optimize sleep quality and strengthen the efficacy of neuroactive substances.

It thus represents a galenic innovation, combining naturalness, efficacy and respect for biological rhythms.

Natural and Vegan Formulation, Labeled Clean Label and High Quality Process

PHYSIOMANCE^® Sommeil LP follows a formulation approach focused on naturalness, favoring ingredients of plant origin, clean processes and a composition that respects the body.

The SEPISMART™ SR technology, which structures the bi-layer tablet, relies exclusively on natural gums from organic agriculture – xanthan gum and acacia gum – extracted without solvents and sourced from renewable plant sources.

This galenic process requires no synthetic agent, no controversial additive and no artificial coating, thus ensuring a physiological release of the actives while respecting the integrity of the raw materials.

The actives themselves have been rigorously selected for their purity, natural origin and synergy of action.

THERASCIENCE Laboratory's commitment to a Clean Label formulation and High Quality Process^®, with no colorants, no preservatives and no unnecessary excipients, makes PHYSIOMANCE^® Sommeil LP a natural, safe solution that respects physiology.

Moreover, THERASCIENCE Laboratory adapts to all dietary habits: PHYSIOMANCE^® Sommeil LP is guaranteed free of gluten-based ingredients and lactose.