Cholesterol is a lipid molecule essential for the proper functioning of the body. In particular, it is involved in the structure of cell membranes, the synthesis of certain hormones and the production of vitamin D.
However, in excess, cholesterol can become harmful. In particular, it promotes the formation of atheromatous plaques on artery walls, a phenomenon called atherosclerosis, which can narrow or block blood vessels. This process significantly increases the risk of serious cardiovascular diseases such as myocardial infarction or stroke.
In addition, excess cholesterol can impair cerebral microcirculation, contributing to cognitive disorders or certain forms of vascular dementia. It is also associated with metabolic disorders, such as metabolic syndrome, which combines hypertension, insulin resistance and excess abdominal fat.
This imbalance may particularly involve LDL cholesterol, known as “bad cholesterol”, which, in excess, tends to accumulate on artery walls in the form of lipid plaques. LDL plays a role in transporting cholesterol from the liver to the cells, but when it is present in excessive amounts, unused cholesterol may be deposited in the blood vessels.
Conversely, a sufficient level of HDL cholesterol, often described as “good cholesterol”, is considered a protective indicator. HDL acts as a cleaning system: it collects excess cholesterol from peripheral tissues and artery walls and carries it back to the liver, where it will be recycled or eliminated. A high HDL level is therefore associated with better regulation of the lipid profile and protection against cardiovascular disease.
Endogenous cholesterol production is largely regulated by a key enzyme: HMG-CoA reductase, which is mainly active in the liver. This enzyme controls hepatic cholesterol production; when its activity is too high, it may lead to endogenous overproduction and therefore an increase in blood cholesterol levels, particularly LDL cholesterol, thereby promoting the risk of cardiovascular disorders.
However, controlling HMG-CoA reductase—whether through nutritional or pharmaceutical means—may negatively affect the biosynthesis of another essential molecule: coenzyme Q10 (CoQ10). Indeed, the metabolic pathways of cholesterol and CoQ10 share common steps, which means that inhibiting the former may also reduce production of the latter.
Some nutritional approaches incorporate targeted active ingredients recognised for their scientific and traditional relevance to metabolism. It is within this context that PHYSIOMANCE® LIPIDEOL 3 was developed, a formula combining three key compounds—Berbessentiel® berberine, red yeast rice (a source of monacolin K) and coenzyme Q10.
Why choose PHYSIOMANCE® LIPIDEOL 3?
PHYSIOMANCE® LIPIDEOL 3 is a formula based on a unique synergy. Each ingredient is rigorously selected, titrated and standardised, ensuring a controlled concentration of active ingredients, full traceability and optimal stability. A concentrate of quality, naturality and scientific expertise. Thus, PHYSIOMANCE® LIPIDEOL 3 contains 365 mg of Berbessentiel® phytosomal berberine, 2.5 mg of monacolin K from red yeast rice, and 12.5 mg of natural, plant-based coenzyme Q10 per ½ tablet daily.
The patented Berbessentiel® extract is obtained from Berberis aristata roots, titrated in phytosomal berberine (microencapsulated with phospholipids), and combined with grape OPCs (ProanthoCyanidolic Oligomers), recognised for their antioxidant action. Thanks to this innovative technology, berberine has 10 times greater bioavailability than a standard extract, with demonstrated efficacy.
Certified High Quality Process and Clean Label, for enhanced naturality, the formula is free from GMOs, colourings, additives and allergens, thereby meeting the most demanding safety and quality standards. PHYSIOMANCE® LIPIDEOL 3 is also suitable for vegans.
What does science say?
The combination of bioactive compounds present in PHYSIOMANCE® LIPIDEOL 3—Berbessentiel® berberine, red yeast rice (monacolin K) and coenzyme Q10—is the subject of sustained scientific interest.
These compounds have been widely studied for their involvement in major metabolic pathways, and their mechanisms of action are well described in the specialised literature.
Nevertheless, to date, no health claim has been authorised under European regulations for these ingredients.
Although no benefit can be officially claimed, these active ingredients are attracting growing interest as part of an appropriate healthy lifestyle.
The benefits of PHYSIOMANCE® LIPIDEOL 3
Berbessentiel® berberine: a highly bioavailable Berberis aristata extract
Berberine is a natural alkaloid extracted from the root of Berberis aristata, a thorny shrub native to the mountainous regions of Asia (the Himalayas, China and India).
Used for centuries in Ayurvedic and Chinese pharmacopoeias, this plant is traditionally recognised for its action on metabolic balance, particularly at the digestive, hepatic and lipid levels.
Its root, rich in bitter compounds, is traditionally used and continues to be employed today in many natural health approaches.
Natural monacolin K from fermented red yeast rice
Red yeast rice (Monascus purpureus) has been used in China for more than 1,000 years, both as a natural food colouring and as a medicinal ingredient in traditional pharmacopoeias.
Produced by fermenting rice with a specific yeast strain, it naturally produces a substance called monacolin K. This molecule has a chemical structure very similar to that of statins and is the subject of extensive research.
Natural coenzyme Q10
Coenzyme Q10 (CoQ10) is a fat-soluble molecule naturally produced by the body that may also be obtained through food or supplementation.
Discovered in 1957 by American biochemist Frederick L. Crane, coenzyme Q10, also known as ubiquinone, plays an essential role in cellular metabolism. In 1978, British researcher Peter D. Mitchell received the Nobel Prize in Chemistry for his work on the electron transport chain, a process in which CoQ10 plays a key role.
CoQ10 is involved in the mitochondrial respiratory chain, an essential process for the production of ATP, the cells’ main source of energy. This function is crucial for organs with high energy requirements, such as the heart, brain and muscles.
10x greater bioavailability thanks to BERBESSENTIEL® phytosomal technology
Berbessentiel® is a registered extract of Berberis aristata root containing phytosomal berberine (microencapsulated with phospholipids). The berberine in Berbessentiel® is combined with grape OPCs (Proantho Cyanidolic Oligomers), which act as antioxidants. This innovative phytosomal formulation is made entirely from natural compounds. The bioavailability of this phytosomal berberine is 10 times greater than that of a standard berberine extract.
Titrated and standardised extracts for optimal efficacy
THERASCIENCE Laboratory has rigorously selected plant extracts standardised and titrated in key active molecules, guaranteeing a precise and consistent concentration of active ingredients with every dose.
Thus, the patented Berberis aristata root extract, Berbessentiel®, is titrated in phytosomal berberine. Thanks to phytosomal technology, bioavailability is up to 10 times greater than that of a standard extract. Each half-tablet of PHYSIOMANCE® LIPIDEOL 3 provides 365 mg of this concentrated extract, guaranteeing a consistent and controlled berberine content.
The red yeast rice extract (Monascus purpureus) is titrated in monacolin K, the active compound naturally present in this yeast. 2.5 mg of monacolin K are provided per half-tablet, according to a guaranteed dosage. This ingredient is rigorously selected in compliance with purity and safety requirements.
Choosing PHYSIOMANCE® LIPIDEOL 3 means opting for a premium, highly dosed formula developed according to the most demanding scientific standards.
Enhanced naturality: ingredients of natural origin, with no additives or GMOs
Committed to a naturality-focused approach, PHYSIOMANCE® LIPIDEOL 3 is based on carefully selected ingredients.
The coenzyme Q10 used in the formula is obtained through a process of natural fermentation and has controlled quality and purity.
It meets the strictest dietary requirements: no gluten- or lactose-based ingredients.
The tablets are formulated without ingredients of animal origin, making them suitable for vegetarian and vegan diets.
PHYSIOMANCE® LIPIDEOL 3 therefore forms part of an approach combining naturality, quality and scientific expertise.
