LIFENOL® : A PATENTED HOP EXTRACT WITH CLINICALLY PROVEN EFFICIENCY ON HOT FLUSHES
Female hop cones are particularly indicated to tackle menopausal disorders. Recent studies have revealed the link between the oestrogenic activity of hops and their concentration of 8-prenylnaringenin, considered as the most active phytoestrogen known so far.
The Lifenol® hop extract present in PHYSIOMANCE Oestronat is a specific extract of female hop cones standardised in prenylflavonoids, including 8-prenylnaringenin. This extract is obtained by a patented process guaranteing the plant profile and its titration in 8- prenylnaringenin. This profile is associated with effectiveness studies on menopausal disorders and, in particular, hot flushes.
A first randomised clinical study was carried out in a double-blind, placebo-controlled settings in 67 menopausal women1.
Health professionals' evaluation was made using the Kupperman index, a scientifically validated test used as a general barometer of menopausal disorders.
After 6 weeks of supplementation with 85 mg of Lifenol® per day, there was a significant reduction in menopausal symptoms, particularly hot flushes, in post-menopausal women :
- More than 2 times less general menopausal discomfort
- 4 times less hot flushes.
A second randomised, double-blind, placebo-controlled crossover clinical study was conducted in 36 postmenopausal women 2.
The efficiency of Lifenol® was self-assessed by the supplemented women through validated questionnaires.
After 8 weeks of supplementation with 85 mg of Lifenol® , the cross-over study shows a strong improvement in the quality of life of menopausal women.
The women would experience :
- 3 times less hot flushes,
- 2 times less night sweats.
Lifenol® hop extract is safe, well tolerated and has no side effects.
(1) ) Heyerick, Arne et al. “A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts.” Maturitas vol. 54,2 (2006): 164-75. doi:10.1016/j.maturitas.2005.10.005
(2) Erkkola, R et al. “A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts.” Phytomedicine : international journal of phytotherapy and phytopharmacology vol. 17,6 (2010): 389-96. doi:10.1016/j.phymed.2010.01.007