PHYSIOMANCE SENOLYTIX provides, for 2 capsules :
- 400 mg of Cotinus coggygria, extract, titrated to 200 mg of fisetin ;
- 400 mg of Quercéfit® quercetin, a registered extract of quercetin in phytosomal form (microencapsulated with phospholipids), guaranteeing 20 times greater bioavailability than a standard extract, and with proven efficacy.
Fisetin and quercetin, two flavonoids against cell senescence
Telomere shortening, DNA degradation, mitochondrial dysfunction and exposure to various epigenetic factors (pollution, stress, sedentary lifestyle, diet, etc.) are all profound biological changes that induce and accelerate cell ageing. This is known as cellular senescence. These so-called senescent cells will gradually accumulate in the body throughout life.
Cells that have become senescent are deformed, unable to divide or perform their function. But the body is also unable to eliminate them, causing them to accumulate. Senescent cells maintain a chronic inflammatory state in the body and sustained neuroinflammation, caused by the secretion of numerous molecules, including cytokines. This phenomenon impacts the surrounding healthy cells and reinforces the ageing process. Several scientific studies have highlighted the link between senescent cells and the onset of age-related diseases.
Research has discovered molecules known as "senolytics", incuding two powerful flavonoids, fisetin and quercetin.
Scientific publications resulting from the research of various international teams can be found on the Pubmed reference site.
Why choose PHYSIOMANCE Senolytix from Laboratory THERASCIENCE ?
PHYSIOMANCE Senolytix is a synergistic combination of two of the most powerful flavonoids: fisetin from Cotinus coggygria, also known as the "wig tree", and Quercéfit® quercetin from Sophora japonica. Our Quercéfit® phytosomal quercetin is microencapsulated in phospholipids.
Phytosomes are small stable spherical lipid vesicles directly involved in the transport of active molecules by means of phospholipids. Each of these phospholipids is associated with a quercetin molecule. The phytosomal form releases quercetin directly into cells in the intestine. Quercefit® quercetin optimises the benefits of this bio-active molecule against senescent cells, guaranteeing up to 20 times greater bioavailability than a standard extract. The phytosomal form improves the efficacy of the active molecule by increasing the absorption of quercetin.
To guarantee the best possible quality, the Sophora japonica extract, from which our Quercefit® quercetin extract is derived, and the Cotinus coggygria extract, which contains fisetin, are regularly checked to ensure that they are free from contaminants. Our High Quality Process® also certifies the bacteriological quality and origin of the plant extracts selected and present in PHYSIOMANCE Senolytix.
To get all the benefits of Quercefit® quercetin and fisetin, PHYSIOMANCE Senolytix is guaranteed GMO-free, nanoparticle-free, preservative-free and gluten and lactose-free thanks to our Clean label THERASCIENCE.
1. Di Pierro et al. International Journal of General Medicine (2021)
2. Di Pierro et al. Frontiers in Pharmacology (2023).
3. Syed, D. N., et al. Anti-cancer agents in medicinal chemistry (2013)
4. Ghafouri-Fard, et al. Biomedicine & Pharmacotherapy (2021)
5. Yousefzadeh, et al. EBioMedicine (2018).
6. Kirkland, et al. EBioMedicine (2017)
7. Wang, L., et al. Oncology letters (2020).