Mitochondrie Gold

Discovered in 1957 by American biochemist Frederick L. Crane, coenzyme Q10 (or ubiquinone) is a fat-soluble molecule naturally produced by the body and also supplied through the diet. It plays a central role in cellular energy metabolism by acting directly within the mitochondrial respiratory chain, a process essential for ATP production.

Pyrroloquinoline quinone disodium salt – PQQ

Less familiar to the general public, PQQ was identified as a bacterial growth factor in the 1970s.

It occurs naturally in certain foods, such as fermented products, green tea and cocoa. PQQ is now the subject of extensive scientific research into its biochemical properties and its potential role in various cellular processes.

Trans-resveratrol

A natural polyphenol found in grapes, peanuts, blackberries and blueberries, resveratrol has long been known for its presence in certain dietary and herbal medicine traditions, particularly in Asia and the Mediterranean region.

It was initially studied in research on red wine, where its polyphenol content attracted researchers’ attention. Today, it continues to generate considerable scientific interest because of its biochemical properties and potential role in various physiological mechanisms. Resveratrol is therefore the subject of numerous studies exploring its use in nutritional and health research contexts.

Ginkgo biloba

Ginkgo biloba is one of the world’s most ancient plants and has been used for thousands of years in traditional Asian pharmacopoeias. Extracts from its leaves contain an exceptionally rich concentration of flavonoids and ginkgolides, natural substances whose properties have been extensively studied.

Laboratoire THERASCIENCE has selected a high-quality, standardised Ginkgo biloba extract, provided at 90 mg per capsule, equivalent to 4.5 g of dried plant material. Each dose therefore supplies 21.6 mg of ginkgoflavonoids, ensuring a precise and consistent concentration of active compounds.

Ginkgo biloba helps maintain healthy cognitive function (memory and concentration), helps maintain memory with age and helps protect cells from oxidative stress.

Its inclusion in the PHYSIOMANCE Mitochondrie Gold formula is consistent with an approach designed to support cognitive functions and overall vitality.

Optimal bioavailability

Bioavailability refers to the rate and extent at which an active ingredient is absorbed into the bloodstream. Depending on its form, an active ingredient will therefore be more readily absorbed and utilised by the body. In other words, a highly dosed active ingredient in a poorly bioavailable form will be less effective than a more bioavailable ingredient at a lower dose. It is therefore essential to select the most bioavailable forms of active ingredients to maximise their efficacy. Laboratoire THERASCIENCE pays particularly close attention to selecting the form of each active ingredient. 

The combination of acetyl-L-carnitine and trans-resveratrol was carefully selected for its high bioavailability: acetyl-L-carnitine is a highly bioavailable form of carnitine, while resveratrol in its trans form offers optimal absorption. Together, these two active ingredients work in a complementary manner to promote optimal assimilation.

Vitamins B2, B6, B9 and B12 are supplied in coenzyme forms. B-group vitamins are a family of water-soluble nutrients that act synergistically and contribute to numerous essential metabolic reactions. Since they do not accumulate in the body, they are not stored and do not pose a risk of overdose. In our products, they are supplied in forms identical to those naturally used by the body, making them more biologically active: vitamin B2 as riboflavin sodium 5′-phosphate, vitamin B6 as pyridoxal 5′-phosphate, vitamin B9 as calcium L-methylfolate and vitamin B12 as methylcobalamin.

Zinc is supplied in bisglycinate form. A randomised study conducted in healthy volunteers compared the oral bioavailability of zinc in gluconate and bisglycinate forms. At an equivalent dose (15 mg), after a seven-day washout period between each intake, the results showed significantly higher bioavailability (+43.4%) for bisglycinate compared with gluconate. This form is also particularly well tolerated by the body.

Selenium is supplied in the form of selenomethionine. This form is obtained from the yeast Saccharomyces cerevisiae, cultured in the presence of sodium selenite. During fermentation, the yeast metabolises the selenite and converts it into organic selenium bound to a molecule of methionine, an essential amino acid. This process produces selenomethionine, recognised as the most bioavailable form of selenium.