SIBO

Acétyl L-Carnitine : rôle, bienfaits

Acetyl-L-Carnitine (ALC) is the acetylated form of L-carnitine, an amino acid derivative naturally produced by the body from lysine and methionine, in the presence of vitamin C, iron and B vitamins. From a physicochemical standpoint, the addition of an acetyl group gives ALC better solubility in water and increased ability to cross biological membranes, particularly the blood-brain barrier, allowing it to be present in both the brain and the peripheral nervous system. The interest in the HCl (hydrochloride) form lies mainly in its galenic and pharmacokinetic advantages, as it forms a more stable salt, highly soluble in water and therefore more easily absorbed by the body. This increased solubility optimizes bioavailability and allows for better consistency of dosages.

In the body, ALC is mainly found in tissues with high energy activity: brain, heart, skeletal muscles and liver. It is involved in the transport of long-chain fatty acids to the mitochondria, where they are oxidized to produce ATP. ALC is involved in the production of acetyl-CoA, a key intermediate of the Krebs cycle and a precursor of acetylcholine, a major neurotransmitter involved in memory, learning, and also motor control.

In the enteric nervous system, nerve transmission and neuromuscular coordination of intestinal motility are of paramount importance. The activity of intestinal neuronal networks is linked to the efficiency of the migrating motor complex (the physiological cleaning process of the small intestine).

Vitacholine™ : stable and highly bioavailable source of choline

VitaCholine™, a registered form of choline, is produced according to strict standards from raw materials of natural origin. Unlike other unstable or poorly absorbed forms of choline, VitaCholine™ offers excellent purity and superior bioavailability.

Choline is an essential nutrient for the body. It is involved in many metabolic processes and plays a major role in prenatal cognitive development, maintaining concentration and memory, and providing energy. It also supports cardiovascular and liver functions, and proper liver function is essential to support fat digestion and overall intestinal metabolism. It is found in many foods (animal liver, eggs, meat, fish, legumes, nuts, etc.), yet a study conducted by NHANES (2003–2004) revealed that average choline intakes are well below adequate levels, both in children (except the youngest) and in men and women (including pregnant women). VitaCholine™ guarantees a superior quality choline, made only with natural L(+) tartaric acid, derived from wine production. This choline has the advantage of being stable and highly bioavailable.

Ginger: a natural ally for digestion, energy and well-being

Ginger (Zingiber officinale Roscoe) is the rhizome of a tropical plant from the Zingiberaceae family, known for its properties on the digestive system, it supports normal intestinal function and promotes good digestion. It has been used for over 2,500 years in Asian, Indian and Arabic pharmacopoeias.

Its richness in phenolic compounds — mainly gingerols. Gingerols are lipophilic phenylalkanoids, responsible for the characteristic pungent flavor of fresh ginger. The most studied molecule is [6]-gingerol.

Ginger, standardized in gingerols, supports good digestion and contributes to normal intestinal function.

Caraway: a digestive plant with recognized virtues

Caraway (Carum carvi L.), also known as meadow cumin, is an herbaceous plant from the Apiaceae family, known since Antiquity for its culinary and medicinal uses. Its aromatic seeds were already mentioned in Greco-Roman medical texts and used in the Middle Ages in Europe as a digestive spice and remedy for intestinal discomfort. From a physicochemical standpoint, the fruits (commonly called seeds) of caraway are rich in essential oil, dominated by carvone and limonene. Carvone is a lipophilic monoterpene ketone responsible for the characteristic aniseed aroma. These molecules are liposoluble and easily volatile, which facilitates their absorption in the intestine. Caraway helps promote digestion while relieving sensations of bloating and flatulence.

Benefits of peppermint in a complete dietary supplement

Peppermint (Mentha × piperita), a hybrid plant resulting from water mint and spearmint, is particularly rich in essential oil concentrated in menthol and menthone. From a physicochemical standpoint, menthol is a lipophilic monoterpene alcohol, crystalline at room temperature, responsible for the characteristic cooling sensation. Menthone, a monoterpene ketone, has a volatile aromatic structure that contributes to the minty aroma and has complementary digestive properties.

These molecules are liposoluble, which promotes their diffusion through biological membranes.

Thus, peppermint helps support good digestion and contributes to normal intestinal function.

Rosemary, a key ingredient in our health formula

Rosemary (Rosmarinus officinalis L.) is an aromatic plant from the Lamiaceae family, rich in phenolic compounds, terpenes and flavonoids. Among these compounds, rosmarinic acid stands out due to its complex polyphenolic structure which gives it high chemical stability and strong water solubility, facilitating its extraction in aqueous preparations.

This structure allows it to chelate certain pro-oxidant metal ions. This means it can strongly bind to metals which, in excess or in certain forms, promote oxidative reactions (free radical production). Standardized dry extracts: concentrate rosmarinic acid and other polyphenols for nutraceutical or phytotherapeutic use with precise dosing.

Safr’Inside^TM : the saffron extract with benefits on mood and well-being

Safr’Inside™, a standardized saffron extract, is the result of an innovative patented process that ensures the stability of active compounds (safranal and crocins), which are usually sensitive to oxidation and heat. This technology protects the active molecules up to the target site and maximizes their absorption at the intestinal level.

Standardized in crocins and safranal, the extract selected by the THERASCIENCE Laboratory, Safr’Inside™, is patented and encapsulated. Safr’Inside™ is the only encapsulated saffron extract preserving the entire molecular spectrum of saffron with more than 25 compounds identified and characterized by U-HPLC method (ultra-high performance liquid chromatography), thus preserving the native composition of saffron. Moreover, Safr’Inside™ retains volatile compounds such as safranal, usually lost during extraction. Safr’Inside™ has the highest concentration in safranal (0.2% U-HPLC) for a complete action on stress.

DigeZyme^® : patented enzyme complex with proven effectiveness

DigeZyme^® is a patented multi-enzyme complex of 100% non-animal origin, while respecting naturalness and tolerance requirements. It combines five major digestive enzymes: alpha-amylase, neutral protease, lipase, cellulase and lactase, each specifically involved in the hydrolysis of macronutrients (carbohydrates, proteins, fats, plant fibers and lactose). Their combined action allows for a more complete breakdown of the food bolus and limits colonic fermentation, often responsible for gas, bloating and digestive discomfort frequently experienced by people with SIBO.

Unlike conventional enzyme complexes often of animal pancreatic origin, DigeZyme^® is obtained through controlled fermentation of GRAS (Generally Recognized As Safe) microorganisms, such as Aspergillus oryzae, Bacillus subtilis, Rhizopus oryzae and Trichoderma longibrachiatum. This process guarantees not only rigorous traceability and reproducibility, but also excellent digestive tolerance. The result is a solution compatible with vegetarian, vegan and clean-label diets. The interest of exogenous enzyme supplementation is even more justified in functional intestinal disorders or pathologies such as SIBO, where the production of endogenous digestive enzymes may be reduced (age, stress, inflammation, hypochlorhydria...). By integrating DigeZyme^® into its formulation, PHYSIOMANCE^® SIBO relies on cutting-edge enzyme technology.

Vitamin B5: an essential nutrient for energy and metabolism

Vitamin B5, or pantothenic acid, is an essential nutrient that plays a central role in many metabolic processes.

It is the direct precursor of coenzyme A (CoA), a molecule essential for energy metabolism and the synthesis of neurotransmitters. Through CoA, vitamin B5 is involved in the formation of acetyl-CoA, an essential precursor of acetylcholine, the main neurotransmitter of the cholinergic axis.

This mechanism is essential for memory, concentration, learning and above all motor function, making vitamin B5 a key player in neuromuscular function.

Clean, natural, 100% vegan formula

Designed according to a rigorous approach to quality and tolerance, PHYSIOMANCE^® SIBO is part of a Clean Label approach that respects even the most sensitive physiological needs. Its formulation excludes any component of animal origin, making it perfectly suitable for people following a vegetarian or vegan diet. The capsules used are 100% plant-based.

Concerned about limiting aggravating factors of SIBO, the product is formulated without FODMAPs (Fermentable Oligo-, Di-, Mono-saccharides And Polyols), fermentable carbohydrates known to trigger bloating, pain and gas in people with digestive hypersensitivity. The absence of FODMAPs in the composition ensures optimal tolerance, even in the most reactive individuals.

This formulation purity meets the highest standards of naturalness, safety and eco-design.