NASH

Rosemary: Aromatic Plant for Liver and Biliary Function

Rosemary (Rosmarinus officinalis L.) is an aromatic plant from the Mediterranean basin, known for its characteristic fragrance and natural richness in active compounds such as ursolic acid. Used in cooking and as an infusion, it can also be consumed as an extract in nutritional preparations.

Rosemary promotes hepatic-biliary drainage and helps support normal liver function. It fits within a varied and balanced diet.

Milk Thistle: Preserve Liver Health and Protection

Milk Thistle (Silybum marianum L.) is a herbaceous plant native to the Mediterranean basin, easily recognizable by its large green leaves marbled with white and its purple flowers. Its fruits contain a natural complex of flavonolignans called silymarin. Used for centuries in European tradition, it is now available as standardized extracts, integrated into various nutritional preparations where it contributes to the liver’s detoxification potential, its protection and proper functioning, and preserves its good health.

3 Amino Acid Derivatives

• Glutathione

Glutathione is a tripeptide naturally present in the body, composed of three amino acids: cysteine, glutamine, and glycine. Glutathione can also be provided by certain plant or animal-based foods and can be used within a varied and balanced diet.
It is produced by cells and found in many tissues, particularly in the liver. Glutathione is a powerful endogenous antioxidant. Antioxidants are particularly important because they help combat oxidative stress responsible for cellular damage caused by free radicals.

• N-Acetylcysteine

N-AcetylCysteine (NAC) is a compound derived from an amino acid, cysteine. NAC is known for its role in glutathione synthesis. By promoting the maintenance of an optimal glutathione concentration in cells, N-acetylcysteine proves to be an essential bioactive.

• L-ornithine-L-aspartate

L-ornithine-L-aspartate is a combination of two amino acids naturally present in the diet: L-ornithine and L-aspartate, found in certain plant and animal protein-rich sources. The body can also produce them from other amino acids. This combination participates in various biological processes that use amino acids as building blocks and is involved in mechanisms related to glutathione metabolism and nitrogen. It can be found in certain nutritional preparations, always within a varied and balanced diet, adapted to individual needs.

Choline: Liver Function and Fat Metabolism

Choline is an essential nutrient naturally found in the diet, particularly in eggs, offal, certain meats, fish, legumes, and oilseeds. It can also be included in nutritional preparations in the form of choline from plant or animal sources. Choline contributes to normal lipid metabolism and to the maintenance of normal liver function.

These properties make it an indispensable nutrient for liver health, particularly in the context of a high-fat lifestyle, which can have long-term impacts. A study conducted by NHANES (2003-2004) revealed that average choline intakes are well below adequate levels, both in children (except the youngest), as well as in men and women (including pregnant women).

Lycopene: A Natural Carotenoid Found in Tomato and Watermelon

Lycopene is a natural pigment from the carotenoid family, responsible for the red color of certain fruits and vegetables such as tomato, watermelon, or pink grapefruit. Present in the diet, it can also be extracted from plant sources to be included in various nutritional preparations. Like other carotenoids, it is part of compounds with antioxidant properties that help restore balance in the body. Its consumption is part of a varied and balanced diet, contributing to the diversity of plant-based nutrients.

Vitamin E: Key Nutrient for Cellular Protection

Vitamin E is a fat-soluble vitamin naturally present in many foods, such as vegetable oils, seeds, nuts, and certain fruits and vegetables. It includes different compounds, notably tocopherols and tocotrienols. Vitamin E contributes to protecting cells against oxidative stress, a phenomenon linked to oxidation that can occur in the body.

It can be extracted from plant sources to be included in nutritional preparations and consumed as part of a varied and balanced diet, helping to meet daily requirements.

Concentrated Plant Extracts for Optimal Efficacy

The THERASCIENCE Laboratory has selected two concentrated and rigorously standardized plant extracts, each titrated in key active molecules to ensure maximum and consistent efficacy. The standardized rosemary leaf extract is highly concentrated with a 50:1 extraction ratio. Additionally, 6 tablets of PHYSIOMANCE^® NASH provide, for 6 tablets, 400 mg of rosemary extract, equivalent to 20 g of dry plant. The rosemary extract is titrated at 30% ursolic acid, representing 120 mg of ursolic acid per daily dose.

The milk thistle seeds contain molecules (flavonolignans) collectively called silymarin. To release all the benefits of this molecule, we have selected a standardized extract with a 20:1 extraction ratio. This means that the 250 mg of milk thistle extract provided by 6 tablets of PHYSIOMANCE^® NASH represents 5 g of dry plant. Finally, our extract is titrated at 80% silymarin, representing 200 mg of silymarin per daily dose.

Thanks to this synergy of concentrated and standardized actives, PHYSIOMANCE^® NASH stands out as a reference in precision, performance, and naturalness.

Optimal Bioavailability

Bioavailability refers to the speed and proportion of absorption of the active ingredient into the blood. Depending on its form, an active ingredient will be better absorbed and assimilated by our body. In other words, a highly dosed active but in a poorly bioavailable form will be less effective than a more bioavailable active at a lower dose. It is therefore essential to choose the most bioavailable form of each active ingredient to maximize efficacy. The THERASCIENCE Laboratory pays particular attention to the selection of each active form. For maximum efficacy, the THERASCIENCE Laboratory has selected actives in the molecular forms most easily assimilated by the body:

• VitaCholine™, a patented form of choline, produced according to strict standards from naturally sourced raw materials. It is made solely with natural L (+) tartaric acid derived from wine production. This choline is stable. Unlike other unstable or poorly absorbed choline forms, VitaCholine™ provides excellent purity and superior bioavailability.
• S-acetyl glutathione is a specific form of glutathione, in which an acetyl group is bound to the glutathione molecule. This structural modification makes it more stable than the classic form. The S-acetyl form is obtained through specific processes from suitable raw materials and can be incorporated into various nutritional formulations.

Natural and Vegan Formulation, Labeled Clean Label and High Quality Process^®

PHYSIOMANCE^® NASH is a dietary supplement with enhanced naturalness, thanks to a rigorous selection of naturally sourced ingredients from environmentally friendly processes. Its formula contains N-acetylcysteine, glutathione, and L-ornithine-L-aspartate naturally derived from plant materials via a fermentation process, ensuring purity and traceability. The included vitamin E is natural, and the product is made without any colorants.

Designed to meet current nutritional requirements, PHYSIOMANCE^® NASH is suitable for vegans, contains no gluten- or lactose-based ingredients, and meets the highest quality standards. It is labeled Clean Label^® and meets the High Quality Process^®, ensuring strict control of every manufacturing step to guarantee safety, performance, and consistent formulations.