Contributes to normal digestion
Gastric acidity lies at the heart of efficient digestion. Produced by the stomach in the form of hydrochloric acid (HCl), it results from the combination of hydrogen ions (H⁺) and chloride ions (Cl⁻). The higher their concentration, the more acidic the pH — a key factor in properly initiating digestion.
An acidic environment (pH between 1 and 3) notably helps activate pepsin, an enzyme essential for the breakdown of proteins found in food, including meat, fish, eggs, legumes, yoghurt, etc. It also promotes the absorption of essential micronutrients (iron, calcium, magnesium, zinc, vitamin B12, etc.). Furthermore, this acidity acts as a first line of defence by destroying most ingested micro-organisms.
When gastric pH increases and becomes less acidic, this is known as hypochlorhydria. This reduction may occur with age, but it may also result from chronic infections, particularly those linked to the bacterium Helicobacter pylori, or persist after discontinuing acid-reducing treatments such as proton pump inhibitors (PPIs).
Insufficient gastric acidity can disrupt digestive balance. It slows protein digestion, promotes feelings of heaviness, bloating and reflux, and impairs the absorption of essential nutrients. In the longer term, it may weaken the gastric barrier and contribute to an imbalance in the intestinal microbiota by promoting the survival of micro-organisms capable of colonising the small intestine, as occurs in SIBO (Small Intestinal Bacterial Overgrowth).
In this context, appropriate supplementation may help restore a gastric environment that supports proper digestion.
PHYSIOMANCE® BETAINE HCL+ is an optimally dosed formula combining 375 mg of betaine HCl with 120 mg of chloride (15% of the NRV), which contributes to normal digestion by supporting the production of hydrochloric acid in the stomach, and 28 mg of pepsin per capsule.
Pepsin is an enzyme involved in the breakdown of proteins found in food. Laboratoire THERASCIENCE has selected a pepsin with a 1:3000 grade, ensuring optimal enzymatic activity. This means that 1 mg of pepsin is capable of processing up to 3000 mg (3 g) of protein, representing up to 84 g of protein processed by 1 capsule of PHYSIOMANCE® BETAINE HCL+ per day, taken at the beginning of a meal.
For enhanced naturalness, PHYSIOMANCE® BETAINE HCL+ is suitable for vegans thanks to its 100% plant-based capsules. This choice ensures an approach that is fully aligned with quality and efficacy requirements.
The bioactive ingredients contained in PHYSIOMANCE® BETAINE HCL+ have undergone an in-depth scientific assessment by the European Food Safety Authority (EFSA):
- Chloride contributes to normal digestion through the production of hydrochloric acid in the stomach.
However, to date, European legislation has not authorised any health claims for betaine and pepsin. Although no specific benefit is officially recognised, betaine and pepsin are attracting growing interest and opening up promising avenues that deserve further exploration.
Furthermore, betaine and pepsin are the subject of numerous scientific studies, and their biological mechanisms of action are extensively documented in the literature. Multiple studies highlight potentially interesting applications.
Betaine is a molecule naturally present in certain plants, particularly beetroot, from which it takes its name. Among its various forms, betaine HCl (betaine hydrochloride) stands out for its specific action: it combines betaine with an acidic component (HCl), directly involved in the gastric environment.
In the stomach, HCl releases hydrogen ions (H⁺), helping to maintain an appropriate level of acidity. This acidic pH plays a central role in the early stages of digestion by contributing to the breakdown of food and supporting the bioavailability of certain essential nutrients such as vitamin B12, calcium, magnesium, iron, etc.
This acidic environment is also essential for the activation of pepsin, a key enzyme involved in protein digestion, enabling proteins to be converted into amino acids that are more easily absorbed by the body.
In this context, betaine in HCl form represents a particularly interesting solution as part of targeted supplementation.
Chloride is an essential electrolyte naturally present in the body and involved in numerous fundamental physiological functions. In the stomach, it plays an essential role in the formation of hydrochloric acid (HCl) by combining with hydrogen ions (H⁺) secreted by the cells of the stomach lining.
The availability of chloride (Cl-) therefore determines the body’s ability to produce a level of acidity suited to its physiological needs. As such, it acts as a key factor in gastric balance, in close connection with digestive mechanisms.
Chloride therefore contributes to normal digestion through the production of hydrochloric acid in the stomach. This is why supplementation may be necessary.
Pepsin is a proteolytic digestive enzyme naturally produced by the stomach. It is secreted in an inactive form, pepsinogen, and then activated in an acidic environment. Its role is to break down dietary proteins into shorter peptides, the first stage of their digestion. These peptides are then processed by other digestive enzymes (trypsin, chymotrypsin and peptidases) to release absorbable amino acids. Therefore, a lack of acidity in the stomach limits pepsin activation and reduces protein breakdown, causing sensations of heaviness, bloating, etc. Pepsin supplementation therefore proves essential.
However, not all pepsins are equal. To ensure optimal efficacy, it is essential to choose a pepsin with a known level of enzymatic activity. This information indicates the amount of protein that the supplied pepsin is capable of breaking down.
Laboratoire THERASCIENCE has selected a 1:3000-grade pepsin, reflecting optimal enzymatic activity. This means that 1 mg of pepsin can digest 3000 mg of protein. PHYSIOMANCE® BETAINE HCL+ provides 28 mg of pepsin per capsule, making it possible to break down up to 84 g of protein, corresponding to a balanced daily intake that can easily be achieved with 2 to 3 portions of animal- or plant-based protein (eggs, meat, dairy products or legumes), and which is consistent with a standard nutritional approach. Indeed, 84 g of protein corresponds approximately to 150 g of chicken breast (45 g of protein), 150 g of salmon (30 g of protein) and 2 eggs (12 g of protein).
Pepsin is a proteolytic digestive enzyme naturally produced by the stomach. It is secreted in an inactive form, pepsinogen, and then activated in an acidic environment. Its role is to break down dietary proteins into shorter peptides, the first stage of their digestion. These peptides are then processed by other digestive enzymes (trypsin, chymotrypsin and peptidases) to release absorbable amino acids. Therefore, a lack of acidity in the stomach limits pepsin activation and reduces protein breakdown, causing sensations of heaviness, bloating, etc. Pepsin supplementation therefore proves essential.
However, not all pepsins are equal. To ensure optimal efficacy, it is essential to choose a pepsin with a known level of enzymatic activity. This information indicates the amount of protein that the supplied pepsin is capable of breaking down.
Laboratoire THERASCIENCE has selected a pepsin with a 1:3000 grade, reflecting optimal enzymatic activity. This means that 1 mg of pepsin can digest 3000 mg of protein. PHYSIOMANCE® BETAINE HCL+ provides 28 mg of pepsin per capsule, making it possible to break down up to 84 g of protein, corresponding to a balanced daily intake that can easily be achieved with 2 to 3 portions of animal- or plant-based protein (eggs, meat, dairy products or legumes), and which is consistent with a standard nutritional approach. Indeed, 84 g of protein corresponds approximately to 150 g of chicken breast (45 g of protein), 150 g of salmon (30g of protein) and 2 eggs (12 g of protein).
Thus, with 4 capsules, PHYSIOMANCE® BETAINE HCL+ can process up to 336 g of protein.
Our products are developed with a genuine commitment to the quality and efficacy of their active ingredients!
Safe use in cases of intolerance: Laboratoire THERASCIENCE adapts to all dietary habits. PHYSIOMANCE® BETAINE HCL+ is guaranteed free from gluten- and lactose-based ingredients. Furthermore, PHYSIOMANCE® BETAINE HCL+ is packaged in 100% plant-based capsules, benefits from the Therascience Clean Label and is suitable for vegans, for enhanced naturalness.
PHYSIOMANCE® BETAINE HCL+ is provided in its most stable and bioavailable form, thereby guaranteeing maximum purity and a 100% natural formula. This is how we offer an authentic formulation, with no compromise on efficacy or quality.
1 capsule per day, at the start of a meal, or according to the advice of your healthcare professional, for a minimum of 3 months. To renew if necessary.
Precautions for use :
Food supplements should be used as part of a healthy lifestyle and not be used as a substitute for a varied and balanced diet. Do not exceed the recommended daily doses. Keep the product out of the reach of young children.
In the event of a combination of several food supplements, ask your healthcare professional for advice.
Betain HCl, plant origin coating: hydroxypropyl methylcellulose, calcium chloride, anti-caking agents : tricalcium phosphate, fatty acid and acacia gum, pepsin.
| For 1 capsule | RI% | |
| Betain HCl | 375,0 mg | |
| Chloride | 120,0mg | 15 |
| Pepsine | 112,0 mg |
*RI : Reference intake
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